Duke is the tournament’s betting favorite thanks to Flagg, the projected No. 1 overall pick in the upcoming NBA draft, and a couple more first-round prospects. The Blue Devils went 19-1 in ACC play and finished the season with the nation’s largest average margin of victory (20.8 points per game). Jon Scheyer’s group is rolling.

Can VCU be one of the 2025 March Madness bracket busters beginning with No. 6 seed BYU on Thursday? Before making any 2025 NCAA Tournament predictions, see the 2025 March Madness bracket picks from the proven computer model at SportsLine.

Madness teams could pull off upsets in the first round? Here's eight bracket-buster predictions for Round of 64 NCAA Tournament bracket.