The expected and wise move from the San Francisco 49ers has come to fruition. Kyle Shanahan announced on Saturday at his final Week 16 press conference that the

The San Francisco 49ers' defense gets a boost ahead of their matchup against the Indianapolis Colts on "Monday Night Football."

The Indianapolis Colts released their final injury report ahead of a crucial Monday Night game against the San Francisco 49ers. Four players have been ruled out, while two are questionable. Among those who are questionable are DeForest Buckner (neck) and Bernhard Raimann (elbow).

Preview the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts with predictions, odds, over/under, spread, betting lines and more.

Preview the NFL Week 16 San Francisco 49ers vs. Indianapolis Colts game with insights, current betting odds including moneyline, spread, over/under and

Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 at Lucas Oil Stadium.

Veteran Philip Rivers' improbable return from retirement ignites a thrilling road game as the 49ers face the surging Colts.

Find out how to watch San Francisco 49ers vs. Indianapolis Colts live streaming online, plus TV channel and game info for this week 16 NFL matchup.