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The creators behind The Big Bang Theory were very intentional in not diagnosing Sheldon Cooper with any conditions that might explain his behavior. Here's why.
One of the funniest (for the audience) yet most brutal (for Sheldon Cooper) incident was when Penny ruined Saturday "laundry" night for him during an interesting "war" that was going on between the two. The incident takes place in Season 2 Episode 7, titled "The Panty Pinata Polarization."
The Big Bang Theory taught its viewers a valuable life lesson using Schrödinger's Cat Theory about how reality remains uncertain until we face it.