San Francisco 49ers wide receiver Brandon Aiyuk hasn't been on the field this year, but he's been a frequent topic of ...

Kyle Shanahan, Christian McCaffrey and more speak to reporters before San Francisco’s practice on Thursday in Santa ...

Tight end George Kittle's wife has partnered with Smirnoff to continue bringing high spirits to the suite amid all the NFL ...

San Francisco 49ers wide receiver Ricky Pearsall will miss Monday night's game against the Indianapolis Colts after re-injuring his knee.

The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster ...

For NFL WAG Sydney Warner, football season is about as busy as it can get this year. With her husband, San Francisco 49ers ...

San Francisco 49ers quarterback Brock Purdy joins NFL Network's "Inside Training Camp Live" to provide a state of the team's ...

The San Francisco 49ers (10-4) enter Week 16 as 5.5-point favorites against the Indianapolis Colts, aiming to extend their ...

A recharged San Francisco 49ers squad returns from a late season break with renewed momentum as quarterback Brock Purdy ...

The Indianapolis Colts have gone 1-5 in their last six games. Key players at impact positions are now out, and the team is ...

The Washington Commanders face the San Francisco 49ers in a big game toward the playoff picture in the NFC. Following their 20-12 loss to the New York Giants, the Commanders have a 35 percent chance ...

The San Francisco 49ers are a National Football League team that plays in the NFC West division. The 49ers have won five Super Bowl titles over the course of their history.