Expert recap and game analysis of the San Francisco 49ers vs. Indianapolis Colts NFL game from December 22, 2025 on ESPN.

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game. The 49ers quarterback powered San Francisco to a 48-27 road victory with a career-high five passing touchdowns.

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns, while George Kittle totaled seven receptions for 115 yards and a TD before leaving the game with an ankle injury.

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The San Francisco 49ers have officially put their playoff destiny in their own hands.

Expert recap and game analysis of the San Francisco 49ers vs. Tennessee Titans NFL game from December 14, 2025 on ESPN.

The San Francisco 49ers may not be playing defense at the level they've played in the past as they approach the postseason, but their offense

The Browns were supposed to get the ball back, but punt return man Gage Larvadain muffed a punt and the 49ers recovered at the Cleveland 18. He had earlier nearly lost a punt to the 49ers, but was able to get on the ball before they recovered it.

Briana Jeannel looks back on San Francisco's Bye week, and Amie Wells joins The Saloon to break down the Week 15 matchup vs. the Tennessee Titans, with sounds from CB Renardo Green, WR Jauan Jennings,