The American Journal of Managed Care

CD4/CD8 Ratio a Useful Predictor of Mortality in Patients Living With HIV

A review found that CD4/CD8 ratio could be used as a prognostic marker for mortality in patients with HIV, though future studies need to be done to confirm these findings. Clinical practices can ...
MedPage Today on MSN

CAR-T Immune Toxicity Linked to Non-Relapse Mortality Risk in Myeloma

Study suggests CD4+ T cells mediate these immune-related toxicities ...
eLife

HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir

In individuals who started antiretroviral therapy during acute HIV infection, the proliferative capacity of HIV-specific CD8+ ...
EurekAlert!

Evolutionary conservation of CD4 and LAG-3 and their cytoplasmic tail motifs with opposing immune functions: do we finally understand LAG-3?

Conservation of their respective cytoplasmic tail motifs, CxC/H in the case of CD4 and an ITIM-like motif in the case of LAG-3, supports that competition between CD4 and LAG-3 for binding of kinase ...
Medscape

High Immune Activation in Patients With Undetectable Viral Loads and Low CD4-Cell Counts

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...
EurekAlert!

Intrinsic factors of the CAR-T cells may play a major role on its clinical success

The development of the CAR-T technology in the recent years has been a major milestone in the fight against cancer. These sort of “living drugs”, T-cells modified to expanse, recognize and attack ...