In an effort to understand how colibactin, a compound produced by certain strains of E. coli, may be connected to the development of colorectal cancer, researchers are exploring how the compound ...

DNA-encoded chemical library technologies are increasingly being adopted in drug discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of chemical spaces four to five ...

A new class of compounds that inhibit bacterial DNA gyrase has been discovered by a team of researchers. An international team of scientists have discovered a new class of compounds that inhibit ...

A simple tweak to a tool for making macrocyclic compounds could help increase the diversity of DNA-encoded libraries used by drug developers to rapidly screen and identify promising drug candidates ...

Minor groove binding compounds represent a diverse class of small molecules that interact with the DNA double helix by inserting into its narrower, minor groove. This mode of binding affords a unique ...

Many anticancer agents interfere with the polymerization step of DNA replication, but these drugs can be toxic to noncancerous cells. Italian researchers have now found a small-molecule kinase ...

People are occasionally exposed to potentially harmful substances in the environment or through their diets or habits. For example, a compound found in cigarette and industrial smoke, benzo(a)pyrene ...

TROY, N.Y. (NEWS10) — An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, according to Rensselaer Polytechnic Institute (RPI). The p53 protein is also known as ...

According to subsection 4 of new §1(a) of the German Patent Act (GPA) implementing EU Directive 98/44/EC, a claim to a naturally occurring DNA sequence must recite the use of the DNA. There appears to ...