A hallmark of type 2 diabetes is the progressive loss of beta cell mass: cells in the pancreas that produce and release ...

Sigma receptors are proteins found on mainly the surface of endoplasmic reticulum (ER) in certain cells. Sigma-1 and sigma-2 are the two main classes of these receptors. The sigma-1 receptor is ...

High concentrations of free fatty acid (FFA) in ketotic dairy cows activate endoplasmic reticulum (ER) stress pathways, ...

Polycystin-2 (PC2), the gene product of one of two genes mutated in dominant polycystic kidney disease, is a member of the transient receptor potential cation channel family and can function as ...

“A lot of what we’ve assumed based on the tools that we had really isn’t true,” study coauthor Craig Blackstone, a cell biologist at the National Institute of Neurological Disorders and Stroke, told ...

Zinc is an essential trace element that controls myriad biological processes. The delicate balance of its concentration in ...

The body's cells change their shape to close gaps such as wounds – with part of the cell flexing depending on the curve of the gap and the organization of cell-internal structures, a new study reveals ...

Glutathione balance in the ER, controlled by SLC33A1, is essential for proper protein folding and disease prevention.