Using human-induced pluripotent stem cell-derived kidney organoids, researchers from Science Tokyo uncovered how abnormal Hippo signaling drives fibrosis in nephronophthisis, a genetic kidney disorder ...
Cell cycle checkpoint-related genes (CCCRGs) are implicated in the development and progression of hepatocellular carcinoma (HCC). However, their precise roles and underlying mechanisms remain ...
Metabolic diseases such as obesity, fatty liver, and insulin resistance are rapidly increasing worldwide, but fundamental ...
The field of cancer epigenetics examines how heritable changes in gene regulation - independent of DNA sequence - impact ...
SAN MATEO, Calif., March 12, 2025 /PRNewswire/ — Vivace Therapeutics, Inc., a small molecule discovery and development company developing first-in-class cancer therapies targeting the Hippo pathway, ...
VT3989, Vivace Therapeutics' Best-in-Class, Hippo Pathway-Targeting Therapy, Demonstrates Promising Antitumor Activity in Refractory Mesothelioma Provided by PR Newswire Oct 19, 2025, 2:30:00 PM ...
Study finds Hippo pathway aberrantly activated in NPH1 models, unveiling Kibra as a potential target
Nephronophthisis (NPH) is a recessive cystic kidney disease responsible for 10% to 20% of pediatric end-stage renal disease cases. NPHP1 (nephrocystin 1) is the most frequently implicated among over ...
The same genes could hold the key to regenerating cells in the ear and eye, according to a new mouse study. Researchers focused on a group of interacting genes called the Hippo pathway, which serve as ...
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