The 8-6 Indianapolis Colts need quarterback Philip Rivers to be more than just a good story amid his shocking return to the NFL if the Colts are to play

Indianapolis Colts' wide receiver Alec Pierce appeared on the team's first Week 16 injury report. Pierce was listed as a limited participant due to an Achilles injury. This past Sunday in Seattle, Pierce played all 60 of the Colts ' offensive snaps in that game.

The Indianapolis Colts and San Francisco 49ers understand the stakes Monday night. Both teams find themselves in the throes of tight division races where one more loss could eliminate them.

Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 at Lucas Oil Stadium.

In the overall AFC playoff picture, the Colts remain on the outside looking in. They are the eighth seed and are one game behind the 9-5 Texans for the final wildcard spot. The other two wildcard teams, the LA Chargers and the Buffalo Bills, are both 10-4.

Since last playing, Philip Rivers has had another child — he has 10 now — and one of his daughters has given birth.

Via Zack Keefer of TheAthletic.com, the Week 15 game between the Colts and the Seahawks was the most-watched Colts game on CBS in Indianapolis in five years. And, of course, five years ago, Rivers was the team’s starting quarterback.

Broadcast and streaming information for the San Francisco 49ers Week 16 'Monday Night Football' matchup against the Indianapolis Colts at Lucas Oil Stadium.

The Indianapolis Colts visit the Seattle Seahawks in NFL Week 15 action: Live updates, score, highlights, Philip Rivers stats.

With Alvin Kamara and rookie Devin Neal sidelined for Week 16, former Indianapolis Colts running back Nyheim Hines signed to the New Orleans Saints’ practice squad, ESPN’s Adam Schefter reported Wednesday.