On the other side, Aston Villa has responded after a slow start to the season. The Lions went winless in their first five matches of the season, but have since responded by coming out on top in their last five, including a 1-0 victory at home against Manchester City last week. Time: 4 p.m. ET Where: Anfield (Liverpool, U.K.)

Liverpool will however be looking to repeat last November's result in the UEFA Champions League league phase against Real, when goals from Alexis Mac Allister and Cody Gakpo gave them a 2-0 win at Anfield. Here's everything you need to know ahead of the game:

Liverpool vs Aston Villa will kick off at 4 p.m. ET/ 1 p.m. PT in the United States. The match will kick off at 8 p.m. local time in Liverpool, England. The match will be shown on multiple TV channels and available to watch through streaming services in the U.S. and the UK.

Villa march north in a different mood. Unai Emery has chiselled resilience and ambition into this squad, a group now comfortable in the Premier League’s sharp company. Winless in their opening six games, they have since lost one of seven, culminating in that eye widening victory against Manchester City. Confidence does not just exist, it travels.

Everything to know as Trent Alexander-Arnold returns to Anfield with Real Madrid for a marquee Champions League showdown

Arne Slot’s Reds were triumphant in an almost identical week this time last year, but only a short time later both they and Real Madrid look very different

Liverpool women's player Mia Enderby had to be stretchered off and rushed to hospital after a neck injury as a mammoth 22 minutes was added on for the match against Tottenham following the lengthy sto

Liverpool returned to winning ways against Aston Villa at the weekend and now prepare for a huge clash against 15-time European champions Real Madrid at Anfield.