The Indianapolis Colts and San Francisco 49ers MNF tilt is regarded as one of the important games left in the season.

Lines are typically sharp this deep into the season, but injuries and quarterback changes can shake things up a lot. There has been some notable NFL line movement in Week 16. Here, we will break down the games that have seen the biggest shifts since lines first opened, with all odds courtesy of DraftKings Sportsbook. Now: Chiefs -3, O/U 37.5

Patrick Mahomes and the faltering Kansas City Chiefs face a must-win clash against the resurgent Houston Texans Sunday on a crunch weekend that features some of the NFL's fiercest rivalries.The Chiefs could hardly be hosting more testing opponents in the weekend's flagship Sunday night game.

One of Josh Allen's WR weapons was fined by the NFL before the Buffalo Bills-Cincinnati Bengals game on Sunday.

Jaylin Lane exited the Commanders heavyweight matchup against the Philadelphia Eagles with an ankle injury, and did not return.

That's the mantra Ben Johnson instilled in his team on Saturday night, with the Chicago Bears pulling off a comeback for the ages in a 22-16 overtime victory over the Green Bay Packers. The win keeps Chicago atop the NFC North and puts the Bears in the driver's seat heading into the final two weeks of the regular season.