Communication between osteoblasts and endothelial cells (ECs) is essential for bone turnover, but the molecular mechanisms of such communication are not well defined. Here we identify Cxcl9 as an ...

Osteoblasts are the cells required for bone synthesis and mineralization, both during the initial formation of bone and during bone remodelling. These cells are present on the bone surface in the form ...

Patients with advanced prostate cancer frequently develop bone metastases. The tropism of prostate cancer cells for bone and their tendency to induce the osteoblastic phenotype is a result of ...

Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects ...

Hypertrophic chondrocytes are deeply involved in the growth of mammalian bones. Researchers find that these cells transform ...

Osteoporosis is the primary cause of bone fractures in the elderly, reflecting an imbalance between osteoclasts, bone-degrading cells, and osteoblasts, bone-building cells. Teriparatide is the only ...

Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation, a new study has found.