In a study with far-reaching implications, scientists have for the first time identified a new in vivo regulatory mechanism for the PH Domain, a component of many proteins that allows them to move ...
Phosphatase and tensin homolog (PTEN), which negatively regulates tumorigenic phosphatidylinositol (3,4,5)-trisphosphate (PIP3) signaling, is a commonly mutated tumor suppressor. The majority of ...
Researchers have better defined a pro-growth signaling pathway common to many cancers that, when blocked, kills cancer cells but leaves healthy cells comparatively unharmed. The study could establish ...
Mutually exclusive distribution of PIP3 and PTEN on the plasma membrane of a migrating cell. (left) A Dictyostelium discoideum cell migrating rightward. The cell expresses PIP3-binding protein tagged ...
The molecular basis of B cell receptor (BCR)-induced apoptosis during the negative selection of immature B cells is largely unknown. We use transitional immature B cells that are highly susceptible to ...
The second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3), formed by the p110 family of PI3-kinases, promotes cellular growth, proliferation, and survival, in large part by activating the ...
In the eukaryotic chemosensory signaling circuit, attractant signals sensed by cell-surface receptors are amplified by a positive feedback loop at the leading edge of the cell. The feedback loop, in ...
SUMMARY At the leading edge of a polarized macrophage, a membrane-based chemotaxis pathway directs cell mi- gration up attractant gradients to sites of infection, inflammation, or tissue damage. Upon ...
MADISON, Wis. -- Researchers from the University of Wisconsin School of Medicine and Public Health and Carbone Cancer Center have better defined a pro-growth signaling pathway common to many cancers ...
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