Prion amyloids, the infectious protein agent of mad cow disease (bovine spongiform encephalopathy, or BSE), and other transmissible spongiform encephalopathies, are protein aggregates with a flair for ...

UCSF scientists have demonstrated for the first time that a change in the folded shape of a prion protein changes its infectious properties—including the prion’s ability to jump “species barriers.” ...

CLEVELAND – July 18, 2013 – A team of researchers from Case Western Reserve University School of Medicine have identified a mechanism that can prevent the normal prion protein from changing its ...

The cellular prion protein has received a lot of attention recently for its potential role in amyloid-β (Aβ) toxicity (see ARF related news story), but that is merely the latest wrinkle in the prion ...

Prion diseases are incurable, deadly neurological disorders that can affect both humans and animals–including Creutzfeldt-Jakob Disease (CJD) in people, Bovine Spongiform Encephalopathy (also known as ...

The virus causing the ongoing COVID-19 pandemic, SARS-CoV-2, has spread far more quickly than any other coronavirus in recorded history. Why is it so contagious? One possibility is that its spike ...

Mammalian prions are notoriously difficult as structural biology subjects, given their insolubility and tendency to aggregate. Researchers have now overcome these challenges to figure out the ...

Prion diseases are incurable, deadly neurological disorders that can affect both humans and animals–including Creutzfeldt-Jakob Disease (CJD) in people, Bovine Spongiform Encephalopathy (also known as ...

Scientists have identified a mechanism that can prevent the normal prion protein from changing its molecular shape into the abnormal form responsible for neurodegenerative diseases. A team of ...

New research brings into focus how prions might be formed and how they can result in different disease outcomes. Prion diseases are incurable, deadly neurological disorders that can affect both humans ...

UCSF scientists have demonstrated for the first time that a change in the folded shape of a prion protein changes its infectious properties -- including the prion's ability to jump "species barriers." ...