The team applied this method to mRNA/saRNA constructs from 1 to 10 kb and assessed pH ranges from 3 to 6. For all the RNA constructs, the J2 immunoblot signal—a marker for dsRNA strands—decreased with ...
SenseUP’s platform tech could overcome the cost and stability hurdles holding back RNAi-based crop protection, claims the ...
The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...
SAN DIEGO--(BUSINESS WIRE)--TriLink BioTechnologies and Alphazyme, both part of Maravai LifeSciences, have collaborated to launch CleanScribe™ RNA Polymerase, a novel enzyme that reduces ...
A Purdue University team has discovered a new therapeutic target for triple-negative breast cancer. The research, led by Kyle ...
Explore RNA interference methods, comparing siRNA and shRNA for gene knockdown, their mechanisms, advantages, and ...
The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), ...
Researchers uncover key mechanisms in gene regulation that may lead to better design of RNA-based medicines. RNA-based medicines are one of the most promising ways to fight human disease, as ...
Multiple forms of double-stranded RNA (blue, magenta, orange structures) cross cell membranes with the help of a conserved protein located in novel sites (colored by depth) throughout the roundworm's ...
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