Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results, researchers are now watching individual molecules collide with cell ...

Histamine is widely known for its role in allergic reactions but also functions as a key neurotransmitter in the brain, where its activity is tightly regulated by the histamine H3 receptor (H3R). In a ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

BUFFALO, N.Y. — When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and ...

Psychedelics, psychoactive substances that alter people's perceptions, mood and thought patterns, have recently shown promise ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 31 (August 2, 2022), pp. 1-8 (8 pages) The bacteria-derived formyl peptide fMet-Leu-Phe (fMLF) is a ...

University at Buffalo neuroscientists have identified the binding site of low-dose ketamine, providing critical insight into how the medication, often described as a wonder drug, alleviates symptoms ...

Researchers have uncovered the structure of a known, widespread human taste receptor, which may help scientists understand the role it plays outside the tongue. “What we found was totally unexpected,” ...

The discovery of insulin nearly a century ago changed diabetes from a death sentence to a chronic disease. This week, a team that includes researchers from Case Western Reserve University School of ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...