It’s been a much different year for the 49ers, who have dealt with major injuries on both sides of the ball, including season-ending ones for Nick Bosa and Fred Warner. Still, they’re sitting at 10-4 with a chance to get the NFC’s No. 1 seed, should they win their final three games of the season.

McCaffrey’s longest run this season has only been 20 yards, but he bounces off tacklers and makes others miss with regularity, like Craig.

The 49ers can clinch a playoff berth in Week 16 with a win over the Colts — or with help before kickoff. Here's how San Francisco gets in.

www.si.com/nfl/49ers/onsi These San Francisco 49ers should make the 2025 Pro Bowl Brian Walshe is set to be sentenced on Thursday after a Massachusetts jury found him guilty of killing and dismembering his wife, the mother of their three children.

She also reveals if it's more stressful to watch Fred play out on the field or have him up in the suite with her

The San Francisco 49ers (10-4) enter Week 16 as 5.5-point favorites against the Indianapolis Colts, aiming to extend their winning streak to five games as they push toward a return to the NFL postseason. With a victory on Monday night at Lucas Oil Stadium, the 49ers would...

Highlighting the San Francisco 49ers interns, their career paths, roles within the organization, and advice for aspiring professionals.

Tight end George Kittle's wife has partnered with Smirnoff to continue bringing high spirits to the suite amid all the NFL madness

A lot of the 49ers' biggest contributors weren't on the team last year. Heck, some of them weren't even on the team in Week 1.