The study of cancer genomics has revealed that both inherited (germline) and acquired (somatic) genetic variations significantly influence cancer ...

The cells in our body acquire genetic changes, known as somatic mutations, throughout our lifetime. With new DNA sequencing technologies, researchers can now analyse these mutations in normal tissues ...

A pivotal study has provided unprecedented insights into the genetic architecture of sweet oranges, highlighting the critical role of somatic mutations in shaping fruit development. By constructing a ...

The mutation in the huntingtin (HTT) gene, which causes the incurable, dominantly inherited Huntington’s disease, was identified decades ago, following one of the most closely watched disease gene ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Genetic disorders can occur due to mutations in one gene (monogenic), multiple genes (multifactorial inheritance), and mutation in one or more chromosomes. Point mutations are where one nucleotide in ...