ascopubs.org

Alternate Statistical Tools and Limitations in Genetic Marker Association Studies in Single-Arm Drug Cancer Trials

In this issue of the Journal, Graziano et al 1 investigate the associations of a number of genotype and haplotype markers with clinical outcome in a sample of patients with metastatic colorectal ...
JSTOR Daily

Inferential Ordinal Correspondence Analysis: Motivation, Derivation and Limitations

Although correspondence analysis has been developed as a descriptive tool, it is shown in this paper that fairly simple intuitive considerations regarding stochastic ordering give rise to estimable ...
Nature

The power of genome-wide association studies of complex disease genes: statistical limitations of indirect approaches using SNP markers

Genome-wide association studies using a dense map of single nucleotide polymorphism (SNP) markers seem to enable us to detect a number of complex disease genes. In such indirect association studies, ...
ascopubs.org

A mismatch between methods and objectives in phase I drug development: Statistical limitations and personalized medicine—A California Cancer Consortium (CCC) study.

Pharmacogenetic study in metastatic colorectal cancer (CRC) patients receiving third-line panitumumab-irinotecan: A GERCOR ancillary study. Phase Ib study of plitidepsin (APL) with gemcitabine (GEM) ...