The ribosome, that protein-making machine, relies on other, smaller machines. For example, it works in concert with a mechanism that supplies amino-acid-carrying tRNAs, including tRNAs that require ...

(A) Bar plot of IARS2 transcription level in different cancer types. (B) TCGA and GTEx databases showed IARS2 transcription level was higher in tumor tissue compared with normal pancreas tissue. (C) ...

Supersulfides, many of which are produced by cysteinyl-tRNA synthetase (CARS), are essential compounds across many different lifeforms. However, the precise physiological roles of CARS-produced ...

University of Washington has divulged compounds acting as methionyl-tRNA synthetase (bacterial) inhibitors reported to be useful for the treatment of bacterial and protozoal infections.

A significant research paper published in the journal Cell Metabolism by the team of Prof. LIU Qiang at the University of Science and Technology of China (USTC) reveals the critical role of glutamate ...

Proteins are built by mixing and matching amino acids, but researchers want to create new functions by adding noncanonical amino acids (ncAAs). However, this process often requires complex whole ...