Uniform protein labeling in intact tissues is a challenge. An approach that allows antibodies to seep within organs could label proteins in millions of cells. Conventional protein-tagging methods, ...

Structural alignment in fibrous tissues like myocardium and tendons is a key biomarker of physiological integrity and ...

Profiling the proteins that cells are making is a staple of studies in biology, neuroscience and related fields because the proteins a cell is expressing at a given moment can reflect the functions ...

When there's a vexing problem to be solved, people sometimes offer metaphorical advice such as "stretching the mind" or engaging in "flexible" thinking, but in confronting a problem facing many ...

Clearing methods allow light to penetrate samples for imaging, although the method used can affect tissue permeability to molecular probes. Conventional labeling protocols involve the slow diffusion ...

A research team has established an optimized three-dimensional (3D) tissue-staining and observation technique based on existing tissue clearing technology. The study details how the new technique can ...

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility. Using the ...

Thyroid cancer is the most common endocrine cancer, affecting more people each year as detection rates continue to rise.

* Context. - The labeling of paraffin blocks and microscopic glass slides in the practice of surgical pathology varies from institution to institution and introduces ...

Tissue processing advance can label proteins at the level of individual cells across whole, intact rodent brains and other large samples just as fast and uniformly as in dissociated single cells. A ...