The fdhF gene encoding the 80-kDa selenopolypeptide subunit of formate dehydrogenase H from Escherichia coli contains an in-frame TGA codon at amino acid position 140, which encodes selenocysteine. We ...

The essential balance of redox reactions, protein synthesis and folding, protection of cell membranes, and integrity of genomic DNA depends on a handful of proteins called selenoproteins that include ...

Living things, from bacteria to humans, depend on a workforce of proteins to carry out essential tasks within their cells. Proteins are chains of amino acids that are strung together according to ...

Selenium is an essential trace element that is cotranslationally incorporated into selenoproteins as selenocysteine, the 21st amino acid. Selenocysteine insertion poses a challenge to the cell, ...

A new study finds that at least one Archaea has surprisingly flexibility when interpreting genetic code, which goes against a ...

A team led by researchers from Charité – Universitätsmedizin Berlin has succeeded in deciphering a fundamental process of molecular biology: the incorporation of selenocysteine – the ‘21st amino acid’ ...

Expression of the murine leukemia virus pol gene occurs by translational read through of an in-frame UAG codon between the gag and pol coding regions. In a previous study, we mutated the UAG codon to ...

The genetics of a marine protozoan may overturn one of the long-held tenets of protein synthesis. According to conventional wisdom, the genetic code is unambiguous: each DNA triplet, or codon, ...

Nuclear-encoded regulatory proteins control mitochondrial translation. A few, however, are encoded by the mitochondrial DNA (mtDNA) and are produced by the mitochondrial translation machinery.

Discover the unique genetic code of Euplotes crassus, where a single codon can represent two amino acids, challenging universal genetics. Living things, from bacteria to humans, depend on a workforce ...