Over-dispersed count data are frequently observed in clinical trials where the primary endpoint is occurrence of clinical events. Sample sizes of comparative clinical trials with these data are ...

The correct application of the variance inflation factor approach for sample size calculations in trials that randomize intact clusters of individuals rests on knowledge of the variance of the outcome ...

To inform continued development of the novel immune agent GEN-1, we compared ovarian cancer patients' end points from a neoadjuvant single-arm phase IB study with those of similar historic clinical ...

Malaria control and elimination is threatened by the spread of insecticide resistance and behavioral adaptation of vectors. Whether mass administration of ivermectin, a broad-spectrum antiparasitic ...

Surgery Versus Ablation for Hepatocellular Carcinoma: A Randomized Controlled Trial (SURF-RCT Trial) and a Nonrandomized Prospective Observational Trial (SURF-Cohort Trial) Personalized dosing of ...

Objective To perform a large-scale pairwise and network meta-analysis on the effects of all relevant exercise training modes on resting blood pressure to establish optimal antihypertensive exercise ...

Glutamine is thought to have beneficial effects on the metabolic and stress response to severe injury. Clinical trials involving patients with burns and other critically ill patients have shown ...

Recent investigation assesses the efficacy of transtracheal versus intravenous administration of 2% lignocaine in mitigating ...