Twenty years after the publication of Fontan's landmark article, he and his colleagues [16] warned about the long-term results of the Fontan operation, expressing the fear that continuing attrition ...

Of the thousands of children born each year with congenital heart defects, a small cohort have severe malformations of their cardiac chambers leading to a single ventricle physiology. The current ...

Patients who have had surgery to create a Fontan circulation show changes in their genetic code, which may provide a new treatment opportunity to reduce premature aging. The procedure is used to treat ...

Researchers from The Children’s Hospital of Philadelphia have identified risk factors for early and late mortality in pediatric cardiac patients who underwent a Fontan operation for single-ventricle ...

In the current issue of Cardiovascular Innovations and Applications, researchers Ahmed Kheiwa, Anushree Agarwal and Anitha John from the Division of Cardiology, Department of Medicine, University of ...

In the current issue of Cardiovascular Innovations and Applications (Volume3, Number 1, 2018, pp. pp. 107-122(X); DOI: 10.15212/CVIA.2017.0041, researchers Ahmed Kheiwa, Anushree Agarwal and Anitha ...

SEOUL, South Korea, Aug. 12, 2025 /PRNewswire/ -- A newly published post-hoc analysis of the landmark FUEL (Fontan Udenafil Exercise Longitudinal) Trial demonstrates that udenafil, a PDE5 inhibitor, ...

SEOUL, South Korea, July 31, 2025 /PRNewswire/ -- Mezzion Pharmaceuticals, Inc. (Mezzion) announced that its confirmatory Phase 3 FUEL-2 study evaluating JURVIGO® (udenafil) 1 in adolescents and young ...

Pediatric heart specialists in the Single Ventricle Care Program provide expert consultation and treatment of the unique issues that arise after the Norwood, Glenn and Fontan operations. For example, ...

The Fontan operation is now among the most common procedures performed to treat complex congenital cardiac defects not amenable to biventricular repair. The advent of the Norwood procedure to treat ...