In the 49ers’ last matchup against the Tennessee Titans, Pearsall injured his ankle on the very first play from scrimmage but ...

Kyle Shanahan challenged Jordan Watkins to be "better than the guys in front of him" to earn snaps. The San Francisco 49ers' ...

San Francisco could suddenly be a dark-horse team to win the NFC West and get the conference's No. 1 overall seed.

The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster ...

The San Francisco 49ers won't play their Week 16 game until Monday night, but they've already benefitted from a massive game ...

Cleveland Browns All-Pro edge rusher Myles Garrett is on the doorstep of NFL history. His 21.5 sacks lead the league by a ...

The Indianapolis Colts can ill-afford a fifth-straight loss when they face the San Francisco 49ers on Monday night.

Niners bolster QB depth with Adrian Martinez's return and scout offensive line talent, preparing for playoff challenges and ...

The Niners’ longtime NFC West foe pulled off a miraculous comeback Thursday against the Rams, erasing a 16-point deficit, ...

The Seahawks were the big winners on Thursday night, moving to 12-3 and opening up a one-game lead over the 11-4 Rams for the ...

NFL reporter Omar Ruiz gives the playoff implication of the San Francisco 49ers vs. the Indianapolis Colts matchup.

USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers ...