T cells are central to adaptive immunity, orchestrating targeted responses against infections and malignancies while forming a durable immunological memory. Memory T cells, particularly CD8+ subsets, ...

Scientists have discovered key genetic factors that determine whether a T cell acts as a powerful disease fighter or enters ...

A multi-institutional study led by researchers at UNC Lineberger Comprehensive Cancer Center, the Salk Institute for Biological Studies, and UC San Diego has uncovered new genetic rules that determine ...

During vaccination, the immune system is purposefully exposed to weakened, inactivated, or a component of pathogens so that the body can recognize their molecular structures in the future and mount a ...

Pre-wired ability in ‘resting’ T cells to remember past viral foes discovered, a promising breakthrough for targeted cancer therapies. A team of immunologists at the University of Massachusetts ...

Even when immune memory cells form in the lung after influenza infection, insufficient dietary iron leaves them less able to mount a strong antiviral response, revealing how nutrition can shape ...

Researchers at the Max Delbrück Center and the University of Oxford have found that a cellular housekeeping function called autophagy—by which cell components are broken down and recycled—plays a ...

A new predictive framework reprograms T cells to sustain immune memory while preserving their ability to fight cancer and infections.

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...