All three members of ESPN are picking the 49ers as well. ESPN's Football Power Index simulation model has the 49ers winning ...

This is the week when the standings start breathing down everyone’s neck. Week 16 brings a full menu of playoff pressure, ...

The Bears enter with a half-game lead over the Packers atop the NFC North. The challenge for Green Bay’s staff is how to ...

The Indianapolis Colts and San Francisco 49ers face off in "Monday Night Football" this week. Check out how to watch on ESPN now.

The 49ers will take on the Colts on Monday, and they'll likely face Philip Rivers. Here's what Kyle Shanahan had to say about ...

Jaguars-Broncos could be the week's biggest showdown, while the Packers and Bears battle in the NFC North. Our writers ...

In the past two games, especially Monday night, Aaron Rodgers showed why he is one of the greatest cold-weather quarterbacks in NFL history, certainly in the past 35 ...

Colts defensive tackle DeForest Buckner told reporters Friday he's still uncertain whether he'll play in Monday Night ...

The Indianapolis Colts will be front and center when they try to pull off the upset against the San Francisco 49ers.

Steelers vs Lions Best bet: Lions team total Over 29.5 (-125) The Detroit Lions are fifth in the league in offensive DVOA, ...

NFL fans around the country were worried about Dallas Cowboys legend Troy Aikman's health this Friday afternoon. Aikman, a three-time Super Bowl champion and Hall of Famer, played for the Cowboys from ...

Here's a closer look at the biggest NFL injuries of Week 16 and what current NFL betting lines look like for the weekend ...