The 2025 draft class is starting to look disappointing for the San Francisco 49ers. On Saturday, the Niners placed rookie ...

San Francisco 49ers wide receiver Brandon Aiyuk hasn't been on the field this year, but he's been a frequent topic of ...

San Francisco 49ers wide receiver Ricky Pearsall will miss Monday night's game against the Indianapolis Colts after ...

For the second time since they traded him, the San Francisco 49ers will face DeForest Buckner and the Indianapolis Colts. Or ...

The Seattle Seahawks took control of the NFC and their division with an OT win over the Rams, but LA and the 49ers aren't ...

Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 ...

San Francisco could suddenly be a dark-horse team to win the NFC West and get the conference's No. 1 overall seed.

It wasn't just the Seahawks celebrating Thursday's night win. The 49ers now have a path to the NFC West title, too.

Here's a look at the studs and duds (and those in between) from the Tennessee Titans' 37-24 loss to the San Francisco 49ers ...

SANTA CLARA, Calif. (AP) — Brock Purdy threw three touchdown passes and the San Francisco 49ers started the stretch run of ...

The San Francisco 49ers' defense gets a boost ahead of their matchup against the Indianapolis Colts on "Monday Night Football ...

The San Francisco 49ers will go into a vital Monday Night Football matchup vs. the Indianapolis Colts without two starters.