The San Francisco 49ers placed linebacker Nick Martin on the Injured Reserve. He’s been out since he suffered a concussion in ...

Christian McCaffrey, who is coming off a one-touchdown, 73-yard rushing performance in his last game, will lead the San ...

McCaffrey’s longest run this season has only been 20 yards, but he bounces off tacklers and makes others miss with regularity, like Craig.

San Francisco 49ers superstar running back Christian McCaffrey has a shot to making franchise history with a team legend in his crosshairs.

San Francisco 49ers head coach Kyle Shanahan addressed WR Ricky Pearsall's status and shared the latest injury updates as the team prepares for Monday's matchup against the Indianapolis Colts.

McCaffrey has dealt with injuries as well, only suiting up for four games in 2024 due to bilateral Achilles tendonitis and a subsequent knee injury that prematurely ended his season. The 2023 ...

Colts coach Shane Steichen said DT DeForest Buckner will return from a neck injury and play vs the 49ers on Monday Night ...

See who's in and who's out for the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts on December 22, 2025.

Preview the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts with predictions, odds, over/under, spread, betting lines and more.