A win in Week 18 would mean the 49ers sweep the Seahawks and win the head-to-head tiebreaker (assuming their records match).

The Indianapolis Colts and San Francisco 49ers understand the stakes Monday night. Both teams find themselves in the throes ...

The Pro Bowl voting just ended for fans, and in a week or two, the teams will be announced. The San Francisco 49ers had a few ...

NBC Sports Bay Area's Matt Maiocco responds to a 49ers fan's take on if Fred Warner can return to play with San Francisco for ...

Brandon Aiyuk hasn't played an NFL game since his serious knee injury in 2024. Here's why he won't be playing at all in 2025.

The Indianapolis Colts host the San Francisco 49ers on " Monday Night Football " in NFL Week 16 action. Both teams are ...

The Tennessee Titans take on the San Francisco 49ers on Sunday, and here are three reasons for optimism in Week 15.

Here's a look at the studs and duds (and those in between) from the Tennessee Titans' 37-24 loss to the San Francisco 49ers ...

SANTA CLARA, Calif. (AP) — Brock Purdy threw three touchdown passes and the San Francisco 49ers started the stretch run of ...

The Tennessee Titans and the San Francisco 49ers meet Sunday in Week 15 in Santa Clara, California, with kickoff slated for 4 ...

Our experts' predictions are in for Tennessee Titans vs. San Francisco 49ers on Sunday. Here's who our experts are picking to ...

Having had an opportunity to watch division rivals attempt to hold serve in a tight playoff race, the San Francisco 49ers and Indianapolis Colts get a chance to help themselves on the field when they ...