Tissue-resident macrophages are present in virtually every organ of the body to execute a variety of vital functions and ...

ABSTRACT: Osteoarthritis (OA) is a degenerative joint disease that is common and significantly impacted in middle-aged and elderly people, and its accompanying inflammatory response plays a crucial ...

1 Graduate School, Youjiang Medical University for Nationalities, Baise, China. 2 Department of Orthopedic Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, ...

Please provide your email address to receive an email when new articles are posted on . Although osteoarthritis is receiving more attention in both the research and clinical arenas than ever, all that ...

Osteoarthritis (OA) is the most common degenerative joint disease worldwide, characterized by synovial inflammation, cartilage loss, and reactive hyperplasia of subchondral bone, affecting the quality ...

Chondrocytes are specialized cells that are essential for cartilage maintenance and repair, and their dysfunction is central to the development of joint diseases like osteoarthritis (OA). However, the ...

(A) UMAP visualization of the 13,363 chondrocytes from healthy human cartilage. Color represents the chondrocyte subset. (B) UMAP visualization of the expression of representative marker genes for ...

GNSC-001 is an investigational, adeno-associated virus gene therapy expressing an optimized form of IL-1Ra. The Food and Drug Administration (FDA) has granted Fast Track designation to GNSC-001 for ...

GNSC-001 is designed to offer long-term, sustained inhibition of IL-1 following a single injection into the affected joint; IL-1 is a key mediator involved in pathogenesis of OA OA affects more than ...

Nearly 33 million Americans have osteoarthritis. Experts explain how it affects the body, and why it’s so hard to diagnose. By Knvul Sheikh It may start as a twinge in your knee or hip when you get ...