The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

NFL Week 10 power rankings shaken up with Denver Broncos and New England Patriots each winning their sixth straight game. Which team should be No. 1?

The Chiefs have head-to-head losses to the Los Angeles Chargers and Jacksonville Jaguars, the two teams directly ahead of it in the wild-card standings. Patrick Mahomes and Co. still have to play the Denver Broncos twice, with the first meeting coming out of Kansas City's bye in Week 11.

The Bills are the new class of the NFL, according to DraftKings Sportsbook oddsmakers. After beating the Chiefs 28-21 on Sunday, Buffalo took over for Kansas City as the Super Bowl favorites, sitting at +600 heading into Week 10. The Chiefs aren’t far behind with +650 odds.

While keeping a positive game script, the Bills out-physicaled the Chiefs and won the line of scrimmage. Running back James Cook went over 100 yards, and establishing that helped Bills quarterback Josh Allen gash the Chiefs defense on another of its weak points this season: play action.