San Francisco 49ers head coach Kyle Shanahan addressed WR Ricky Pearsall's status and shared the latest injury updates as the team prepares for Monday's matchup against the Indianapolis Colts.

The San Francisco 49ers placed linebacker Nick Martin on the Injured Reserve. He’s been out since he suffered a concussion in ...

San Francisco 49ers superstar running back Christian McCaffrey has a shot to making franchise history with a team legend in his crosshairs.

Colts coach Shane Steichen said DT DeForest Buckner will return from a neck injury and play vs the 49ers on Monday Night ...

McCaffrey’s longest run this season has only been 20 yards, but he bounces off tacklers and makes others miss with regularity, like Craig.

See who's in and who's out for the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts on December 22, 2025.

Christian McCaffrey, who is coming off a one-touchdown, 73-yard rushing performance in his last game, will lead the San ...

Defensive coordinator Robert Saleh and offensive coordinator Klay Kubiak discussed the team's matchup prep, highlighted key ...

It can be tempting for the San Francisco 49ers to overlook the Indianapolis Colts this week. After starting the season 7-1, ...

The 49ers running game has been up and down, but they could have an advantage against a very solid Colts run defense ...

The Indianapolis Colts will be front and center when they try to pull off the upset against the San Francisco 49ers.

The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.