The conflict in the Middle East has already led to the closure of huge swathes of crucial airspace. Since Israel launched its offensive, commercial flights have avoided flying over Iran, Iraq, Lebanon, Syria and Jordan.

Under the reign of Ayatollah Ruhollah Khomeini, Iran, once America and Israel's closest ally in the Middle East, became their bitterest enemy

Countries in the Middle East have criticized the U.S. strikes on Iran's nuclear sites, calling for diplomacy. Meanwhile, Israel and Iran have continued to trade strikes. CBS News' Debora Patta has more.

President Donald Trump announced Monday that Israel and Iran have agreed to a ceasefire, which he said will end the 12-day exchange of attacks between the countries in a conflict that prompted concerns of significant destabilization of the Middle East.

By Steve Holland, Andrew Mills and Parisa Hafezi WASHINGTON/DOHA/ISTANBUL (Reuters) -U.S. President Donald Trump announced on Monday a complete ceasefire between Israel and Iran, potentially ending the 12-day war that saw millions flee Tehran and prompted fears of further escalation in the war-torn region.