The US administration has extended its line of attack on academia from US federal research to private universities. The abuse ...

Although student mobility is being restricted in a less dramatic fashion than currently in the USA, the impact on science ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...

Phosphatidylserine (PS) is a phospholipid mainly enriched in the inner leaflet of the plasma membrane; however, its role in the nucleus remains unclear. This study describes the presence of PS in the ...

Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis ...

imageimageAn evolutionarily conserved micropeptide, Sertm2, encoded by the lncRNA A730046J19Rik, promotes Etv4+ motor neuron subtype specification by GDNF, proper neurite development, and motor ...

Immuno-Metabolic Mechanisms of Atherosclerosis (2020) Atherosclerosis remains a leading cause of death worldwide, characterised by plaque build-up in artery walls. Dysregulation of lipid homeostasis ...

De novo protein design is of fundamental interest to synthetic biology, with a plethora of computational methods of various degrees of generality developed in recent years. Here, we introduce ...

Poorly energized mitochondria trap a subpopulation of mitochondrial precursor proteins in the intermembrane space. This article introduces ‘mitochondrial triage of precursor proteins’ (MitoTraP) as a ...

Algorithms that constrain metabolic network models with enzyme levels to predict metabolic activity assume that changes in enzyme levels are indicative of flux variations. However, metabolic flux can ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Studying the human immune system in vivo is ...

CAR T-cell therapy may lead to secondary malignancies, posing challenges to current pharmacovigilance concepts.