Although 49ers receiver Ricky Pearsall reinjured the knee that kept him out of six games earlier this season, coach Kyle ...

JJ Stankevitz from the Indianapolis Colts previews Week 16 "Monday Night Football", with one-on-one interviews featuring San ...

The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

Tennessee Titans defensive tackle Jeffery Simmons is grateful his mother wasn’t at his house watching him on TV when burglars ...

NFL Insider Tom Pelissero breaks down the playoff clinching scenarios around the NFL in Week 16. San Francisco 49ers have a shot to clinch on "Monday Night Football" with a win. Watch the NFL's ...

San Francisco 49ers wide receiver Ricky Pearsall has missed the team's first practice of the week due to knee and ankle ...

It's another week of multiple players on the San Francisco 49ers missing from practice. At this point in the season, it's a ...

San Francisco would have a better chance at the No. 1 seed in the NFC playoffs if Seattle can pull off the victory at home.

INDIANAPOLIS — The Indianapolis Colts and San Francisco 49ers understand the stakes on Monday night. Both find themselves in ...

The Indianapolis Colts are just trying to get into the playoffs. The San Francisco 49ers are playing for a division title and ...

Brock Purdy had no excuses against the Tennessee Titans and had to have a big game against their weak pass defense. Fortunately for the San Francisco 49ers, the ...

The San Francisco 49ers are preparing for their Week 16 contest against the Indianapolis Colts on Monday night at Lucas Oil ...