ApoE and Tweety Homolog 2—Proteins that Flock Together?
Jul 11, 2025 · The role of ApoE has been well-studied outside of the cell, but what happens after it’s let inside? Scientists led by Raimund Dutzler, University of Zurich, have identified Tweety homologue 2 …
APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
Apr 27, 2024 · These results indicate a delay in endosome-to-lysosome maturation, with lysosomes failing first. Calcium levels in lysosomes also fell by 30 percent in the 24 hours after DAPT. Bretou …
When SORL1 Dimerizes in Endosomes, Retromers Recycle APP Faster
Feb 2, 2023 · Indeed, they found that SORL1 dimers in the endosome existed almost entirely in complex with retromer. How might SORL1 dimerization influence the recycling and processing of APP? To …
Toward an AD CRISPR Therapy: Tweaking APP Terminus Cuts Plaque
Jun 27, 2024 · Researchers led by Subhojit Roy at the University of California, San Diego, used CRISPR gene editing to remove a six-residue motif that targets APP to the endosome, where β-secretase, …
Partners in Crime: APP Fragment and Endosomal Protein Impair ...
Jul 21, 2015 · The small GTPase rab5, which switches on in AD, regulates endosome trafficking and drives these changes (see Stenmark, 2009; Cataldo et al., 2008). Nixon reported that the β-CTF …
Interactions between TTYH2 and APOE facilitate endosomal lipid …
Jul 11, 2025 · An interesting avenue for future research is to better characterize the interactions that ApoE undergoes as the endosome matures and fuses with the lysosome. Do other proteins take …
Spatial snapshots of amyloid precursor protein intramembrane …
Park H, Hundley FV, Yu Q, Overmyer KA, Brademan DR, Serrano L, Paulo JA, Paoli JC, Swarup S, Coon JJ, Gygi SP, Wade Harper J. Spatial snapshots of amyloid precursor protein intramembrane …
Endosomal Dysfunction Induced by Directly Overactivating Rab5 ...
Jan 13, 2021 · A strength of the paper is that the authors go on to use the new mouse model to explore different pathological consequences for increased Rab5a activation and endosome dysfunction on …
Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
May 4, 2024 · That works for the type 1 integral membrane proteins that form its usual cargo, because such proteins, as with SORL1, will be endocytosed and the two will therefore encounter each other in …
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta ...
Jan 26, 2010 · It is established that overexpression of APP, such as in Down syndrome, leads to endosome dysfunction. The article by Jiang et al. (1) now elegantly shows that the endosomal …