🚨 Low SHBG Is a Red Flag — Not a Goal ✅ Higher SHBG = lower risk of: • Type 2 diabetes • Coronary artery disease • Atherosclerosis And this isn’t just correlation — it’s causal. 🧪 Mendelian randomization studies (which use genetic proxies to eliminate confounders) show that people born with lower SHBG have higher risk of: • Metabolic syndrome • Ischemic heart disease • Coronary heart disease 📚 Key references: • Ding et al., NEJM 2009 → Low SHBG independently predicts diabetes • Perry et al.,
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🚨 Low SHBG Is a Red Flag — Not a Goal ✅ Higher SHBG = lower risk of: • Type 2 diabetes • Coronary artery disease • Atherosclerosis And this isn’t just correlation — it’s causal. 🧪 Mendelian randomization studies (which use genetic proxies to eliminate confounders) show that people born with lower SHBG have higher risk of: • Metabolic syndrome • Ischemic heart disease • Coronary heart disease 📚 Key references: • Ding et al., NEJM 2009 → Low SHBG independently predicts diabetes • Perry et al.,
313 viewsMay 11, 2025
FacebookDr. Joel MD
SHBG: Why It’s Important and How to Manage It
SHBG: Why It’s Important and How to Manage It
Mar 10, 2025
zendesk.com
Testosterone Action vs Testosterone Levels: Why SHBG Matters - Unlocking Insights - Explore Our Articles
Testosterone Action vs Testosterone Levels: Why SHBG Matters - Unlocking Insights - Explore Our Articles
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Sex hormone binding globulin (SHBG) is commonly WAY oversimiplified. Many people tend to think it's only purpose is used for calculating the free testosterone. But this undermines its clinical utility. Believe it or not, but the SHBG can give us insight into whether or not the patient has liver disease, thyroid disease, metabolic disease/insulin resistance, as well as PCOS. Furthermore, it can be used to help direct frequency of drug administration as well as the drug's metabolism. Make sure tha
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